2,3-Dihydroquinazolin-4(1H)-one as a privileged scaffold in drug design
نویسندگان
چکیده
منابع مشابه
Quinoline scaffold as a privileged substructure in antimicrobial drugs
Drug design is a complex issue that still lack general approach with proven reliability. Combinatorial chemistry and HTS techniques did not appear to be effort-effective. As an alternative we have the fragment based design and more recently so called the privileged structures approach. We believe that some structural subunits are especially effective in design of bioeffectors. However it is not...
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Many naturally occurring substances, traditionally used in popular medicines around the world, contain the coumarin moiety. Coumarin represents a privileged scaffold for medicinal chemists, because of its peculiar physicochemical features, and the versatile and easy synthetic transformation into a large variety of functionalized coumarins. As a consequence, a huge number of coumarin derivatives...
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ژورنال
عنوان ژورنال: RSC Advances
سال: 2018
ISSN: 2046-2069
DOI: 10.1039/c8ra02827c